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Virus derived immunostimulatory RNA induces type I IFN

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Virus-derived immunostimulatory RNA induces type I IFN-dependent antibodies and T-cell responses during vaccination - ScienceDire

Adjuvants potentiate and direct the type of immunity elicited during vaccination. However, there is a shortage of adjuvants that elicit robust type-1 immunity required for the control of intracellular pathogens, including viruses. RNA derived from Sendai virus defective ...

Activation of the MDA-5 IPS-1 Viral Sensing Pathway Induces Cancer Cell Death and Type I IFN-Dependent Antitumor Immuni

also execute its antiviral activity by inducing death of virus-infected cells in a type I IFN-independent manner (9, 10). In ... TRAMP-C2 cell line was derived from a prostate tumor that aroseinatransgenicadenocarcinomaofmouseprostate(TRAMP) mouse on a ...

Induction of type I interferon by RNA viruses: cellular receptors and their substrates | SpringerLi

Through numerous studies RIG-I and MDA5 have been found to play a key role in IFN induction following RNA virus infection. ... Weiss SR (2008) Murine coronavirus mouse hepatitis virus is recognized by MDA5 and induces type I interferon in brain PubMed ...

Genomic HIV RNA Induces Innate Immune Responses through RIG-I-Dependent Sensing of Secondary- Structured R

Genomic HIV RNA Induces Innate Immune Responses through RIG-I-Dependent Sensing of Secondary-Structured RNA Randi K. Berg1, ... whereas only low levels of type I IFN and tumor necrosis factor a were produced. Furthermore, secondary structured HIV ...

EP2338499A1 - 5' triphosphate oligonucleotide induces anti-viral response - Google Paten

Bacterial RNA also induces type I IFN production. 5' triphosphate oligonucleotides and bacterial RNA can be used for inducing an anti-viral response or an anti-bacterial response, ...

A Hamster-Derived West Nile Virus Isolate Induces Persistent Renal Infection in Mice — UTMB Research Expert Profil

/ A Hamster-Derived West Nile Virus Isolate Induces Persistent Renal Infection in Mice. In: PLoS Neglected Tropical Diseases. 2013 ; Vol. 7, No. 6. ...

Virus-derived immunostimulatory RNA induces type I IFN-dependent antibodies and T-cell responses during vaccinatio

Virus-derived immunostimulatory RNA induces type I IFN-dependent antibodies and T-cell responses during vaccination. Vaccine. 2018; 36(28) ...

WO2001022990A2 - Methods related to immunostimulatory nucleic acid-induced interferon - Google Paten

Methods and compositions are provided for extending the clinical utility of IFN-α in the treatment of a variety of viral and proliferative disorders. Among other aspects, the invention provides methods which increase the efficacy of IFN-α treatment and reduce IFN-α ...

"Myxoma virus induces type I interferon production in murine plasmacytoid dendritic cells via a TLR9/MyD88-, IRF5/IRF7-, and IFNAR-dependent .

not with vaccinia virus, induces IFN-alpha, IFN-beta, tumor necrosis factor (TNF), and interleukin-12p70 (IL-12p70) ... Using pharmacological inhibitors, we demonstrate that myxoma virus-induced type I IFN and IL-12p70 production in murine pDCs is also ...

Immunostimulatory RNA oligonucleotides trigger an antigen-specific cytotoxic T-cell and IgG2a response | Blood Journ

We show that isRNA activates dendritic cells and induces production of Th1-type cytokines both in vitro and in vivo. ... Immunostimulatory RNA oligonucleotides trigger an antigen-specific cytotoxic T-cell and IgG2a response Carole Bourquin, Laura Schmidt, Veit ...

PACT- and RIG-I-Dependent Activation of Type I Interferon Production by a Defective Interfering RNA Derived from Measles Virus Vaccine._J Virol .

UNLABELLED:The live attenuated measles virus vaccine is highly immunostimulatory. Identification and characterization of its components that activate the innate immune response might provide new strat ... PACT- and RIG-I-Dependent Activation of Type I ...

Modulation of mRNA Translation and Cell Viability by Influenza A Virus Derived Nonstructural Protein 1 | Nucleic Acid Therapeuti

Translation of in vitro transcribed messenger RNA (mRNA) is known to be compromised by cell's innate immune responses. Herein we show that when mRNA encoding nonstructural protein 1 (NS1), an immune evasion gene derived from influenza A virus, is co ...

Autocrine Interferon Priming in Macrophages but Not Dendritic Cells Results in Enhanced Cytokine and Chemokine Production after Coronavirus .

Here, we show that an animal coronavirus, mouse hepatitis virus, induces IFN and other IFN-responsive molecules in macrophages, ... (MHV)-infected bone marrow-derived macrophages (BMM) produce type I IFN at late times p.i. (A) BMM or bone marrow and ...

Evidence for a Novel Mechanism of Influenza Virus-Induced Type I Interferon Expression by a Defective RNA-Encoded Prote

Evidence for a Novel Mechanism of Influenza Virus-Induced Type I Interferon Expression by a Defective RNA-Encoded Protein ... The first evidence of an influenza DI RNA inducing IFN expression came from DI 244 which protected wild type mice from lethal but ...

Type I interferons in anticancer immuni

Type I interferons (IFNs) were first discovered more than half a century ago as the factors underlying viral inter ... induces type I IFN production by DCs24. DCs from Tmem173−/ − mice are defective at priming CTLs specific for tumour associated antigens ...

学术活动:Highly immunostimulatory RNA derived from a Sendai virus defective viral genome-空军军医大学基础部 医学微生物学教研

Highly immunostimulatory RNA derived from a Sendai virus defective viral genome ... Abstract Defective viral genomes (DVGs) are generated during virus replication. DVGs bearing complementary ends are strong inducers of dendritic cell (DC) maturation and of the ...

Vaccine | Vol 36, Issue 28, Pages 3993-4152 (27 June 2018) | ScienceDirect.c

select article Virus-derived immunostimulatory RNA induces type I IFN-dependent antibodies and T-cell responses during vaccination ... Virus-derived immunostimulatory RNA induces type I IFN-dependent antibodies and T-cell responses during vaccination ...

Evidence for a Novel Mechanism of Influenza Virus-Induced Type I Interferon Expression by a Defective RNA-Encoded Protein. | PubFac

Evidence for a Novel Mechanism of Influenza Virus-Induced Type I Interferon Expression by a Defective RNA-Encoded Protein. Toggle navigation Sign In Join Now Categories Authors Videos Journals Stories Login Categories Authors Videos Journals Stories ...

Innate immune response to homologous rotavirus infection in the small intestinal villous epithelium at single-cell resolution | PN

EW replicates in IEC subsets differing in their basal type I IFN transcription and induces IRF3-dependent and IRF3-augmented transcription, ...

Evidence for a Novel Mechanism of Influenza Virus-Induced Type I Interferon Expression by a Defective RNA-Encoded Protein. | Sigma-Aldri

Furthermore, small subgenomic RNAs are known to be strong inducers of pattern recognition receptor RIG-I-dependent type I interferon (IFN) responses. The present study identifies a novel IAV-induced defective RNA derived from the PB2 segment of A/Thailand/1 ...