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Abstract B168 The PARP inhibitor niraparib crosses the

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Janssen has agreed to supply the PARP inhibitor niraparib, facilitating the potential initiation of a PARP inhibitor combination trial with SRA737 for the treatment of prostate cancer ...

Veliparib with temozolomide or carboplatin/paclitaxel versus placebo with carboplatin/paclitaxel in patients with BRCA1/2 locally recurrent .

Veliparib (ABT-888) is a potent, orally bioavailable, selective PARP-1/2 inhibitor that crosses the blood–brain barrier []. Veliparib monotherapy has demonstrated antitumor activity in BRCA+ ...

Metastatic breast cancer: The Odyssey of personalization - Sonnenblick - 2016 - Molecular Oncology - Wiley Online Libra

PARP inhibitors“BRCAness” biomarkerPrecision medicine trialsImmunotherapyVEGFA as biomarker of response ... Lapatinib has been the focus of particular interest in this setting as it crosses the blood–brain barrier, with a response rate of 30% when given). ...

Publications - The Institute of Cancer Research, Lond

The CST Complex Mediates End Protection at Double-Strand Breaks and Promotes PARP Inhibitor Sensitivity in BRCA1-Deficient Cells. ...

USE OF A COMBINATION OF DBAIT MOLECULE AND PARP INHIBITORS TO TREAT CANCER - INSTITUT CUR

Abstract: The present invention relates to the combination of a PARP inhibitor with a Dbait molecule for treating cancer. Inventors: Dutreix, Marie (L'HAY-LES-ROSES, FR) Jdey, Wael (LONGJUMEAU, FR) Application Number ...

New Directions in the Management of Recurrent Ovarian Cancer: Focus on PARP Inhibito

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Barriers to Effective Drug Treatment for Brain Metastases: A Multifactorial Problem in the Delivery of Precision Medicine | SpringerLi

The PARP inhibitor, niraparib, crosses the blood brain barrier in rodents and is efficacious in a BRCA2-mutant intracranial tumor model. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics ...

Maintenance Therapy for Ovarian Cancer: Practical Considerations for Community Practi

The PARP inhibitor, niraparib, crosses the blood brain barrier in rodents and is efficacious in a BRCA2-mutant intracranial tumor model [AACR abstract B168]. Mol Cancer Ther. 2015;14(12 suppl 2). Meehan RS, Chen AP. New Gyn Onc Res Pract. 2016;3 ...

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Minnesota, discusses the association between aromatase inhibitors, endothelial function, and early heart disease (Abstract S5-07). symptom management breast cancer The ASCO Post / 2016 San Antonio Breast Cancer Symposium Jame Abraham ...

Veliparib with temozolomide or carboplatin/paclitaxel versus placebo with carboplatin/paclitaxel in patients with BRCA1/2 locally recurrent .

Veliparib (ABT-888) is a potent, orally bioavailable, selective PARP-1/2 inhibitor that crosses the blood–brain barrier []. Veliparib monotherapy has demonstrated antitumor activity in BRCA+ ...

US20180362972A1 - Use of a combination of dbait molecule and parp inhibitors to treat cancer - Google Paten

The present invention relates to the combination of a PARP inhibitor with a Dbait molecule for treating cancer. ... is not clear. It has been proposed that Veliparib could be type (i) and Olaparib, Niraparib, BM673 could belong to type (ii). Moreover, as PARP is the ...

Modelling covariance structure in the analysis of repeated measures data - Littell - 2000 - Statistics in Medicine - Wiley Online Libra

Abstract The term ‘repeated measures’ refers to data with multiple observations on the same sampling unit. ... The effect of stillbirth on reproductive and productive performance of pure Egyptian buffaloes and their crosses with Italian buffaloes, , 10.1016/j, ...

Profile of veliparib and its potential in the treatment of solid tumo

In this regard, veliparib was inferior to both niraparib and olaparib in trapping PARP. This finding may be related to the period of time that PARP is “trapped” onto the DNA, ...

TESARO Announces Data Presentations for Niraparib at the 2015 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics .

Saturday, November 7, 2015, 12:30 PM to 3:30 PM The PARP inhibitor, niraparib, crosses the blood brain barrier in rodents and is efficacious in a BRCA2-mutant intracranial tumor model Abstract: B168, Location: Session B, Hall C-D

Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma | Nature Communicatio

Mirza, M. R. et al. Niraparib maintenance therapy in platinum-sensitive, recurrent ovarian cancer. N. Engl. J. ... O. et al. Secondary somatic mutations restoring RAD51C and RAD51D associated with acquired resistance to the PARP inhibitor rucaparib in high 7 ...

Leveraging Evidence to Optimize Applications of PARP Inhibitor Strategies in Ovarian Cancer | P

The PARP inhibitor, niraparib, crosses the blood brain barrier in rodents and is efficacious in a BRCA2-mutant intracranial tumor model. ... Abstract nr B168. doi: 10.1158/1535-7163.TARG-15-B168. http://mct.aacrjournals.org/content/14/12_Supplement_2/B168. ...

Abstract B168: The PARP inhibitor, niraparib, crosses the blood brain barrier in rodents and is efficacious in a BRCA2-mutant intracranial tumor .

Download Citation on ResearchGate | Abstract B168: The PARP inhibitor, niraparib, crosses the blood brain barrier in rodents and is efficacious in a BRCA2-mutant intracranial tumor model | Introduction The incidence of brain metastases among breast and ovarian ...

Abstract B168: The PARP inhibitor, niraparib, crosses the blood brain barrier in rodents and is efficacious in a BRCA2-mutant intracranial tumor .

The PARP inhibitor, niraparib, crosses the blood brain barrier in rodents and is efficacious in a BRCA2-mutant intracranial tumor model. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; ...

Janssen to Present Data from Robust Oncology Portfolio and Pipeline at the 2019 ASCO Annual Meeting, Including Best of ASCO Selections - NASDAQ.c

Niraparib is an orally-administered selective poly ADP ribose polymerase (PARP) inhibitor that is currently being studied for the treatment of patients with prostate cancer by Janssen. In April 2016, Janssen entered a worldwide (except Japan) collaboration and for ...

TESARO Announces Data Presentations for Niraparib at the 2015 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics .

The PARP inhibitor, niraparib, crosses the blood brain barrier in rodents and is efficacious in a BRCA2-mutant intracranial tumor model Abstract: B168, Location: Session B, Hall C-D Saturday, November 7, 2015, 12:30 PM to 3:30 PM