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HLA B27 natural function and pathogenic role in

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HLA-B27, Annual Review of Immunology | 10.1146/annurev-immunol-032414-112110 | DeepDy

but the pathogenic role of HLA-B27 is unknown. Two broad theories most likely explain the role of HLA-B27 in AS pathogenesis. The first is based on the natural immunological function of HLA-B27 of presenting antigenic peptides to cytotoxic T cells or ...

HLA-B27: natural function and pathogenic role in spondyloarthritis - Open Access Libra

This chapter will first describe the natural function of HLA-B27, before presenting possible mechanisms by which HLA-B27 might be involved in disease pathogenesis. We will review the data available from HLA-B27 transgenic animals, from structural studies a...

HLA-B27: natural function and pathogenic role in spondyloarthrit

The human leukocyte antigen HLA-B27 is strongly associated with development of a group of inflammatory arthritides collectively known as the spondyloarthritides. We have set out to define the natural immunological function of HLA-B27, and then to apply this knowledge to understand its pathogenic

HLA-B27: natural function and pathogenic role in spondyloarthritis. — The Kennedy Institute of Rheumatolo

The human leukocyte antigen HLA-B27 is strongly associated with development of a group of inflammatory arthritides collectively known as the spondyloarthritides. We have set out to define the natural immunological function of HLA-B27, and then to apply this ...

HLA-B27 — Википедија, слободна енциклопедиј

Gen HLA-B27 je smešten na hromozomu 6p21.3. i sastoji se od niza sa najmanje 31 vrlo sličnih alela, HLA-B2728 do B2701 koji nose naziv HLA. HLA-B27 je poznat od 1985. Antigen se sastoji od 6 podtipova, no nikakva povezanost ne postoji između pojedinih ...

Progress in our understanding of the pathogenesis of ankylosing spondylitis | Rheumatology | Oxford Academ

The arthritogenic peptide theory proposes that HLA-B27 plays a central pathogenic role in the presentation of joint-specific peptides to CD8 + cytotoxic T cells. ...

Review Aetiology and pathogenesis of reactive arthritis: role of non-antigen-presenting effects of HLA-B

theories have been proposed to clarify the pathogenic role of HLA-B27 [3-7], many of them based on the idea that classical function of HLA-B27, antigen presentation to T cells, is ...

Application of a Simple In-House PCR-SSP Technique for HLA-B* 27 Typing in Spondyloarthritis Patients - Open Access Libra

HLA-B27: natural function and pathogenic role in spondyloarthritis HLA typing in systemic sclerosis Pyrosequencing? : A one-step method for high resolution HLA typing Ultraspecific probes for high throughput HLA typing Statistical Resolution of Ambiguous ...

Regulating the Immune Response - LabCo

HUMAN LEUKOCYTE ANTIGEN B27 | A TECHNICAL REVIEW Considerable evidence supports a direct role for HLA-B*27 in genetic susceptibility to ankylosing spondylitis (AS) and related spondyloarthropathies (SpA).1 There is a higher prevalence of this ...

HLA B27 allele types in homogeneous groups of juvenile idiopathic arthritis patients in Latvia | Pediatric Rheumatology | Full Te

Recent researches revealed the importance of this molecule in the function of natural killer cells []. It is found out, that HLA B27 is not a single allele, but it represents a highly homologous HLA B alleles family, called types of alleles and denoted as HLA B*2701 ...

HLA-B gene - Genetics Home Reference - N

Several variations of the HLA-B gene increase the risk of developing ankylosing spondylitis, particularly a version called HLA-B27. It is uncertain how this variation causes the increased risk. Researchers speculate that HLA-B27 may abnormally display peptides that ...

Etiopathogenic role of HLA-B27 alleles in ankylosing spondylit

the possibility of involvement of pathogenic mechanisms unrelated to its physiological function. Moreover, HLA-B27 is not a single allele, but a family of 31 different alleles, named HLA-B*2701 to HLA-B*2727. Studies ...

HLA-B27: natural function and pathogenic role in spondyloarthritis | Request P

Request PDF on ResearchGate | HLA-B27: natural function and pathogenic role in spondyloarthritis | Chapter summary The human leukocyte antigen HLA-B27 is strongly associated with development of a group of inflammatory arthritides collectively known as the ...

Association of ankylosing spondylitis with HLA-B27 and ERAP1: Pathogenic role of antigenic peptide - ScienceDire

Association of ankylosing spondylitis with HLA-B27 and ERAP1: Pathogenic role of antigenic peptide Author links open overlay panel Bin Chen Dahe Li Weidong Xu Show more ...

Gene–gene interactions of HLA-B27 ERAP1 in ankylosing spondylitis: finding the pieces of the puzz

Role of HLA-B27 in AS The remarkable association of HLA-B27 with development of AS and related forms of arthri - tis grouped under the term spondyloarthritis ...

HLA-B27

Possession of the human leukocyte antigen (HLA) class I molecule B27 is strongly associated with ankylosing spondylitis (AS), but the pathogenic role of HLA-B27 is unknown.

HLA-B27: natural function and pathogenic role in spondyloarthritis (pdf) | Paperi

HLA-B60 and B61 are strongly associated with ankylosing spondylitis in HLA-B27-negative Taiwan Chinese patients HLA-B27: natural function and pathogenic role in spondyloarthritis Arthritis Research & Therapy, May 2002 Andrew McMichael Paul Bowness ...

PLOS ONE: Increased Levels of IgG Antibodies against Human HSP60 in Patients with Spondyloarthrit

In order to clarify a potential connection between HLA-B27 and the role of human HSP60, more studies, focusing on HLA-B27, ... McMichael A, Bowness P (2002) HLA-B27: natural function and pathogenic role in spondyloarthritis. Arthritis Res 4 Suppl 3: S153

The Role of Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) in the Pathogenesis of Ankylosing Spondylit

For assessing the peptide trimming function, surface HLA-B27 and MHC-I free heavy chain (FHC) expression on peripheral blood mononuclear cells of AS patients were studied. ...

HLA-B27 — Vikipedija, slobodna enciklopedi

The pathogenetic role of HLA-B27 and its subtypes. Autoimmun Rev. 2007 Jan;6(3):183-9. PMID 17289555. ^ A. McMichael, P. Bowness. HLA-B27: natural function and pathogenic role in spondyloarthritis. Arthritis Res. 2002;4 Suppl 3:S153-8 ...

HLA-B27 | Annual Review of Immunolo

I molecule B27 is strongly associated with ankylosing spondylitis (AS), but the pathogenic role of HLA-B27 is unknown. ... This review describes the natural function of HLA-B27, its disease associations, and the current theories as to its pathogenic role. ...